Targeting CDC42 Protects Mitochondrial Function through KLF2/HIF-1α/PINK1 Signaling in Acute Kidney Injury

International Journal of Biological Sciences 2026 Open access

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Authors: Xue Zhou, Xian Fu, Yi-Wen Meng, Ping Dai, Qing Jiang, Hou-Hua Yin, Qing-Jin Pan, Ai-Zhi Lin, Kai-Di Ni, Ziguo Luo, Ru-Yu Liang, Yi-Yu Chen
+2 more Hai‐Xin Yuan, Jun-Yan Liu
DOI: 10.7150/ijbs.125930
Cited by: 5

Abstract

transcriptional cascade, thereby promoting mitophagy and restoring mitochondrial homeostasis. Functional assays supported that this pathway plays a pivotal role in protecting RTECs from oxidative damage. Collectively, these findings uncover a previously unrecognized role of CDC42 in AKI pathogenesis and highlight CDC42 inhibition as a promising therapeutic strategy for mitigating mitochondrial damage and improving renal outcomes.

Fields of Study & Subjects

Acute Kidney Injury Research Kruppel-like factors research Chemotherapy-induced organ toxicity mitigation

Publication details

Journal / source
International Journal of Biological Sciences
Publisher
Ivyspring International Publisher
Volume
22
Issue
3
Pages
1247–1265
Publication date
1 January 2026
Language
EN