Delactylase effects of SIRT3 on a positive feedback loop involving the RUNX1-glycolysis-histone lactylation in diabetic kidney disease

International Journal of Biological Sciences 2026 Open access

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Authors: Siman Shen, Chen Chu Ying, Xinglin Fu, Xiaobian Zeng, Xiuli Guo, Han Wu, Liangqing Zhang, Li Xu
DOI: 10.7150/ijbs.126011
Cited by: 7

Abstract

Thus, the study links RUNX1-mediated glycolysis to SIRT3-mediated histonelactylation epigenetic reprogramming in promoting the fibrotic process, providing better understanding of epigenetic regulation of DKD pathogenesis, and new therapeutic strategy for DKD.

Fields of Study & Subjects

Sirtuins and Resveratrol in Medicine Biochemical and Molecular Research Biochemical Acid Research Studies

Publication details

Journal / source
International Journal of Biological Sciences
Publisher
Ivyspring International Publisher
Volume
22
Issue
4
Pages
1775–1792
Publication date
15 January 2026
Language
EN