Targeting Macrophage-to-Myofibroblast Transition Mitigates Progression from Inflammation to Fibrosis in Rosacea

International Journal of Biological Sciences 2026 Open access

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Authors: Chengqian Chen, Peiru Wang, Yajing Cao, Dongbin Sung, Yutong Yang, Jin Yang, Jia Liu, Yu Yan, Zhijie Ruan, Jie Dong, Jia Yan, Qihang Chang
+4 more C. Li, Xiaojing Liu, Xiuli Wang, Qingyu Zeng
DOI: 10.7150/ijbs.128841
Cited by: 1

Abstract

. BA directly targeted STAT3 and interfered with its palmitoylation-dependent activation, thereby disrupting profibrotic and inflammatory signaling. Our findings establish MMT as a driver of fibrotic remodeling in rosacea, define STAT3 palmitoylation as a therapeutic target, and position BA as a dual-acting candidate for mechanism-based intervention.

Fields of Study & Subjects

Acne and Rosacea Treatments and Effects Pharmacological Effects of Natural Compounds Endoplasmic Reticulum Stress and Disease

Publication details

Journal / source
International Journal of Biological Sciences
Publisher
Ivyspring International Publisher
Volume
22
Issue
5
Pages
2361–2382
Publication date
4 February 2026
Language
EN