Suppression of ASNS expression by VHL-mediated ubiquitination hinders the progression of renal cell carcinoma through enhancing JUP expression and inhibiting PI3K-AKT and MAPK pathways

International Journal of Biological Sciences 2026 Open access

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Authors: Wuping Yang, Tao Liu, Wenwei Ying, Minghao Lu, Dan Xia, Tianyu Tang, Ding Peng
DOI: 10.7150/ijbs.129332
Cited by: 0

Abstract

. In summary, our findings highlighted the critical role of L-Asn in RCC and identified ASNS as a novel substrate for VHL-mediated ubiquitination, presenting a potential new target for RCC treatment.

Fields of Study & Subjects

Renal cell carcinoma treatment Ubiquitin and proteasome pathways Cancer Hypoxia and Metabolism

Publication details

Journal / source
International Journal of Biological Sciences
Volume
22
Issue
6
Pages
3048–3069
Publication date
26 February 2026
Language
EN