PSMC5 Orchestrates an Immunosuppressive Niche and Metastasis in Colorectal Cancer via SMURF1-Mediated K11-Linked Ubiquitination of METTL14

International Journal of Biological Sciences 2026 Open access

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Authors: Yi Zhang, Xiao Yang, Hua Zhong, Chengsheng Ding, Ximo Xu, Yanfei Shao, Bin Sun, Wendong Zhang, Junjun Ma, Bo Feng, Minhua Zheng, Zirui He
DOI: 10.7150/ijbs.130350
Cited by: 1

Abstract

, SMURF1 silencing restored METTL14 expression and attenuated PSMC5-driven tumor growth and lung metastasis. Collectively, these findings define a PSMC5/SMURF1/METTL14 axis that links proteasomal regulation to epitranscriptomic remodeling and metastatic progression in CRC, and identify this pathway as a candidate therapeutically actionable axis.

Fields of Study & Subjects

Ubiquitin and proteasome pathways Mechanisms of cancer metastasis Melanoma and MAPK Pathways

Publication details

Journal / source
International Journal of Biological Sciences
Publisher
Ivyspring International Publisher
Volume
22
Issue
10
Pages
5182–5202
Publication date
11 May 2026
Language
EN