Redirecting Cholesterol Metabolism During Ex Vivo Biomanufacturing Enhances the Metabolic Fitness and Antitumor Efficacy of CAR-T Cells

International Journal of Biological Sciences 2026 Open access

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Authors: Yuge Zhu, Jiaxin Tu, Shuang Li, Shance Li, Bufan Xiao, Xuantong Zhou, Guanyu Zhang, Xinyu Li, You He, Nan Wu, Zheming Lu, Chaoting Zhang
DOI: 10.7150/ijbs.132207
Cited by: 1

Abstract

-dependent mitochondrial metabolism is required for CAR-T cell functional improvements conferred by FL. These findings establish cholesterol metabolism as a tunable axis during CAR-T cell manufacturing and propose a clinically feasible, GMP-compatible strategy to enhance CAR-T cell fitness and therapeutic efficacy.

Fields of Study & Subjects

CAR-T cell therapy research Transgenic Plants and Applications Viral Infectious Diseases and Gene Expression in Insects

Publication details

Journal / source
International Journal of Biological Sciences
Publisher
Ivyspring International Publisher
Volume
22
Issue
10
Pages
5228–5245
Publication date
11 May 2026
Language
EN