Targeting QRICH1 suppresses epithelial-mesenchymal transition and tumor growth in liver cancer through the Connexin43/USP1 mediated Snail1 stabilization
Abstract
, QRICH1 knockdown significantly inhibited tumor growth and reduced the expression of USP1, Snail1, PCNA, VEGF, and N-cadherin, while increasing E-cadherin and Connexin43. Collectively, these findings identify QRICH1 as a key oncogenic regulator that promotes liver cancer progression by stabilizing Snail1 via USP1-dependent deubiquitination and disrupting Connexin43-mediated gap junction signaling.
Fields of Study & Subjects
Connexins and lens biology
Proteoglycans and glycosaminoglycans research
Ion Channels and Receptors
Publication details
- Journal / source
- International Journal of Biological Sciences
- Publisher
- Ivyspring International Publisher
- Volume
- 22
- Issue
- 11
- Pages
- 6177–6195
- Publication date
- 10 June 2026
- Language
- EN