Fibrillin-1 Orchestrates a Pro-senescent Niche Driving Peritubular Endothelial Senescence via ZEB1/endothelin-1/β-catenin Signaling

International Journal of Biological Sciences 2026 Open access

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Authors: Junxin Huang, Xiaoyao Zhang, Zifu Yao, Yuxi Zhang, Di Huang, Yongsi Liu, Fan Fan Hou, Youhua Liu, Li Li (14993)
DOI: 10.7150/ijbs.133521
Cited by: 1

Abstract

deletion suppresses endothelial senescence, attenuates capillary rarefaction, and ameliorates renal function across CKD models. Our study unveils the FBN1/ZEB1/ET-1/β-catenin axis as a spatially organized signaling pathway linking to endothelial senescence, demonstrating how matrix-embedded components actively perpetuate pathogenesis by orchestrating stable pathological microenvironments. These findings provide a conceptual framework for CKD-associated vascular deterioration and highlight microenvironmental reprogramming as a therapeutic paradigm.

Fields of Study & Subjects

Telomeres Telomerase and Senescence Connective tissue disorders research Corneal surgery and disorders

Publication details

Journal / source
International Journal of Biological Sciences
Publisher
Ivyspring International Publisher
Volume
22
Issue
11
Pages
5911–5933
Publication date
29 May 2026
Language
EN