The Adjunctive Role of Hyperbaric Oxygen Therapy in Microbial Infection-Related Conditions
Abstract
Hyperbaric oxygen therapy (HBOT) demonstrates expanding applications in infectious diseases through its multimodal mechanisms. As an adjunctive treatment, HBOT directly exerts antimicrobial effects through oxygen toxicity and reactive oxygen species generation, while indirectly enhances host immunity by improving neutrophil function and promoting tissue repair. Clinical evidence supports its adjunctive use in complex infections including diabetic foot wounds, necrotizing soft tissue infections, COVID-19, and mucormycosis, particularly in hypoxic wounds where conventional therapies show limited efficacy. While current studies are promising, further randomized trials are needed to standardize protocols and confirm efficacy.
Fields of Study & Subjects
Diabetic Foot Ulcer Assessment and Management
Legionella and Acanthamoeba research
Streptococcal Infections and Treatments
Publication details
- Journal / source
- International Journal of Medical Sciences
- Publisher
- Ivyspring International Publisher
- Volume
- 23
- Issue
- 6
- Pages
- 2154–2165
- Publication date
- 11 May 2026
- Language
- EN