NPM1 phosphorylation-mediated telomere maintenance via stabilization of POLD3 in ALT-positive osteosarcoma: unraveling mechanisms and therapeutic opportunities

Theranostics 2026 Open access

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Authors: Rui Zhao, Tingfang Li, Qiuhui Yang, Duo Jiang, Yanan Xue, Haomeng Kou, Qianqian Wang, Yuwen Wang, Xinyu Han, Wenbin Ma, Guowen Wang, Jinyan Feng
+8 more Xiuxin Han, Yancheng Liu, Yaqing Jing, Xin Geng, Fei Wang, Yang Janet Liu, Qiang Zhang, Feng Wang
DOI: 10.7150/thno.108662
Cited by: 1

Abstract

This study uncovers a novel CST/pT199-NPM1/POLD3 regulatory module that is critical for ALT telomere maintenance in OS. Targeting NPM1 or its downstream effectors effectively suppresses ALT activity and enhances chemotherapy response. These findings provide new mechanistic insights into telomere regulation in ALT-positive tumors and highlight the therapeutic potential of NPM1-centered pathways in OS.

Fields of Study & Subjects

Telomeres Telomerase and Senescence Nuclear Structure and Function Microtubule and mitosis dynamics

Publication details

Journal / source
Theranostics
Publisher
Ivyspring International Publisher
Volume
16
Issue
8
Pages
4224–4244
Publication date
22 January 2026
Language
EN