Galectin7 attenuates abdominal aortic aneurysm progression by resisting disturbed flow induced endothelial-to-mesenchymal transition

Theranostics 2026 Open access

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Authors: Yanbing Wang, Yanbing Wang, Yilin Zhou, Yeshen Zhang, Danni Tu, Guojun Chen, Yuan Han, Xiaomin Wei, Yanmei Chen, Senlin Huang, Wangjun Liao, Wangjun Liao
+5 more Jiancheng Xiu, Yuegang Wang, Yuegang Wang, Jianping Bin, Xinzhong Li
DOI: 10.7150/thno.117785
Cited by: 1

Abstract

EndMT transformation in ECs exposed to d-flow was the critical driver of AAA development. Furthermore, endothelium-enriched galectin-7 suppressed the EndMT process induced by d-flow and prevent AAA progression by transcriptionally inhibiting SRGN via competitive binding with CREB to restrict TGFβ/smad pathway.

Fields of Study & Subjects

Aortic aneurysm repair treatments Galectins and Cancer Biology IL-33 ST2 and ILC Pathways

Publication details

Journal / source
Theranostics
Publisher
Ivyspring International Publisher
Volume
16
Issue
7
Pages
3665–3684
Publication date
8 January 2026
Language
EN