Imaging CRISPR-edited CAR-T cell therapies with optical and positron emission tomography reporters

Theranostics 2026 Open access

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Authors: Rafael Enrique Sanchez-Pupo, J. J. Kelly, Nourhan Shalaby, Ying Xia, Francisco Manuel Martinez-Santiesteban, Jasmine Lau, Ivy Elizabeth Verriet, Matthew Stefan Fox, Justin W. Hicks, Jonathan D. Thiessen, John A. Ronald
DOI: 10.7150/thno.119013
Cited by: 2

Abstract

tRACE-CAR enables precise optical and PET tracking of CRISPR-edited CAR-T cells in models of leukemia and ovarian cancer, allowing dynamic, non-invasive monitoring of cell distribution in both tumors and off-target tissues. This imaging-enabled platform could lead to more personalized, effective CRISPR-edited CAR cell therapies.

Fields of Study & Subjects

CAR-T cell therapy research CRISPR and Genetic Engineering bioluminescence and chemiluminescence research

Publication details

Journal / source
Theranostics
Publisher
Ivyspring International Publisher
Volume
16
Issue
7
Pages
3227–3245
Publication date
1 January 2026
Language
EN