Therapeutic targeting of the AMPK-Has1 complex formation ameliorates metabolic dysfunction-associated steatohepatitis in mice

Theranostics 2026 Open access

Read full text
Authors: Xunzhe Yin, Wenjing Zhao, Li Yang, Chang Li, Xiangyu Guo, Lihao Lin, Zuojia Liu, Jin Wang
DOI: 10.7150/thno.120527
Cited by: 1

Abstract

Ele protects against MASH by interrupting AMPK/Has1 interaction, regulating lipid metabolism, and restoring mitochondrial function. Collectively, these findings highlight Ele as a potential therapeutic agent and Has1 as a novel target for MASH treatment.

Fields of Study & Subjects

Liver Disease Diagnosis and Treatment Protein Tyrosine Phosphatases Fibroblast Growth Factor Research

Publication details

Journal / source
Theranostics
Publisher
Ivyspring International Publisher
Volume
16
Issue
8
Pages
4260–4282
Publication date
22 January 2026
Language
EN