Targeting the FOSL1/IKKα positive feedback loop attenuates glioblastoma malignancy via suppression of NF-κB signaling

Theranostics 2026 Open access

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Authors: Beichen Zhang, Hao Ming Tian, Haoyu Zhou, Yichang Wang, Ke Gao, Yiyang Cao, Mingjing Zhou, Maode Wang, Wei Wu, Jia Wang
DOI: 10.7150/thno.121770
Cited by: 0

Abstract

The findings of this study establish a previously unrecognized FOSL1/IKKα/UCHL3 positive feedback loop as a central driver of GBM pathogenesis through activation of NF-κB signaling, providing a promising molecular target for future GBM therapeutic strategies.

Fields of Study & Subjects

Ubiquitin and proteasome pathways NF-κB Signaling Pathways Endoplasmic Reticulum Stress and Disease

Publication details

Journal / source
Theranostics
Volume
16
Issue
7
Pages
3338–3362
Publication date
1 January 2026
Language
EN