CK2-mediated HDAC5 shuttling regulates DNA end resection through Ku70 deacetylation

Theranostics 2026 Open access

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Authors: Xueyi Liang, Jingyuan Zhao, Shoukang Li, Ruozheng Wei, Haixin Yu, Qiyue Zhang, Qixun Fu, Gengdu Qin, Yuhan Zhao, Jiaying Liu, Zhiqiang Liu, Tao Peng
+6 more Junpeng Meng, Shanmiao Gou, Tao Yin, Heshui Wu, Bo Wang, Yingke Zhou
DOI: 10.7150/thno.122935
Cited by: 1

Abstract

These findings uncover a previously unrecognized CK2-HDAC5-Ku70 signaling axis that governs DNA repair pathway choice by regulating DNA end resection. Targeting this axis provides a mechanistic rationale for enhancing PARP inhibitor sensitivity in PDAC, including tumors without classical homologous recombination deficiency.

Fields of Study & Subjects

Histone Deacetylase Inhibitors Research PARP inhibition in cancer therapy Epigenetics and DNA Methylation

Publication details

Journal / source
Theranostics
Publisher
Ivyspring International Publisher
Volume
16
Issue
7
Pages
3648–3664
Publication date
8 January 2026
Language
EN