MUC20 alleviates kidney fibrosis by modulating pyroptosis through the MET/RAS/STING axis

Theranostics 2026 Open access

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Authors: Jiaxin Huang, Zhoutong Chen, Fengbo Zhong, Rui Zheng, Dexin Zhang, Jingyi Su, Yi Zhong, Xiaoliang Fang, Dali Li, Yuting Guan, Hongquan Geng
DOI: 10.7150/thno.123986
Cited by: 1

Abstract

MUC20 acts as a key protective regulator in kidney by restraining RAS-cGAS-STING-NLRP3-driven pyroptosis and fibrotic progression. Targeting MUC20-related signaling pathways may offer therapeutic potential for kidney fibrosis and chronic kidney disease.

Fields of Study & Subjects

interferon and immune responses Inflammasome and immune disorders Ferroptosis and cancer prognosis

Publication details

Journal / source
Theranostics
Publisher
Ivyspring International Publisher
Volume
16
Issue
8
Pages
4374–4393
Publication date
4 February 2026
Language
EN