Nanobody Nb07 mitigates sepsis by blocking the PFKM-p53-PD-1 axis to enhance macrophage phagocytosis

Theranostics 2026 Open access

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Authors: Binbin Ji, Hui Guo, Rong Xing, Miaomiao Sun, Yu Cheng, Chen Yao, Hanyong Zhu, Xuerong Wang, Ruihan Jiang, Xin Chen, Zimeng Liu, Suyan Wang
+6 more Fei Xu, Fangyu Zhang, Fuxing Dong, Xiucheng Pan, Jing Yang, Yuchen Pan
DOI: 10.7150/thno.124303
Cited by: 0

Abstract

Our data reveal the PFKM-p53-PD-1 axis that suppresses macrophage phagocytosis in sepsis and highlight the therapeutic potential of targeting this pathway with nanobody-based strategies.

Fields of Study & Subjects

Immune cells in cancer Phagocytosis and Immune Regulation Cancer Hypoxia and Metabolism

Publication details

Journal / source
Theranostics
Volume
16
Issue
7
Pages
3408–3425
Publication date
1 January 2026
Language
EN