Histone H4K8 lactylation promotes glioblastoma progression by inducing NUPR1-mediated autophagosome‒lysosome fusion

Theranostics 2026 Open access

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Authors: Jiangli Zhao, Xuchen Liu, Yanya He, Sun Q, Zhiwei Xue, Ziyi Tang, Junzhi Liu, Jiwei Wang, Chao Li, Xinyu Wang, Ning Yang, Chen Qiu
DOI: 10.7150/thno.126579
Cited by: 4

Abstract

In summary, this study defines the functional and prognostic significance of histone lactylation in the progression of GBM. We identified the H4K8la-NUPR1 axis as a key regulatory pathway that mediates protective autophagy and developed targeted therapeutic strategies to disrupt this pathway. These findings provide novel insights into epigenetic regulation and targeted therapy for GBM.

Fields of Study & Subjects

Autophagy in Disease and Therapy RNA Research and Splicing Sirtuins and Resveratrol in Medicine

Publication details

Journal / source
Theranostics
Publisher
Ivyspring International Publisher
Volume
16
Issue
8
Pages
4427–4451
Publication date
4 February 2026
Language
EN