Microvascular endothelial metabolic dysfunction drives cerebral edema through bioenergetic failure after ischemia-reperfusion

Theranostics 2026 Open access

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Authors: Yi-Fan Zhou, Sibo Yang, Feng Zhang, Xiaodi Sun, Bo-Hao Chang, Ya-Nan Li, Jie-Hong Wu, Hui-Juan Jin, Ming Huang, Sheng-Cai Chen, Hang Yang, Dong-Ya Zhu
+2 more Bijoy K Menon, Bo Hu
DOI: 10.7150/thno.127083
Cited by: 10

Abstract

Aberrant lactate metabolism not only serves as a prognostic biomarker but also provides a mechanistic link between metabolic insufficiency and epigenetic dysregulation through histone lactylation. Targeting the feedback loop involving H3K18la and ATF4-DDIT4 offers a promising therapeutic approach to limit cerebral edema and improve functional outcomes after ischemic stroke.

Fields of Study & Subjects

Single-cell and spatial transcriptomics Barrier Structure and Function Studies Neuroinflammation and Neurodegeneration Mechanisms

Publication details

Journal / source
Theranostics
Publisher
Ivyspring International Publisher
Volume
16
Issue
7
Pages
3577–3598
Publication date
1 January 2026
Language
EN