BMAL1 regulates tubular epithelial-derived exosomal miR-27a-3p to inhibit macrophage–myofibroblast transition and alleviate ischemia/reperfusion-induced renal fibrosis

Theranostics 2026 Open access

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Authors: Chen Wu, Sheng Zhao, Songyuan Yang, Weimin Yu, Ting Rao, Xiangjun Zhou, Yuan Ruan, Fan Zou, Fan Cheng, Wei Li
DOI: 10.7150/thno.127538
Cited by: 1

Abstract

Rationale: in IRI-induced renal fibrosis is still unclear. Methods: investigations were conducted. Results: signaling pathway and ultimately attenuating MMT and renal fibrosis. Conclusions: pathway. Targeting this signaling pathway may offer a potential therapeutic strategy for alleviating IRI-induced renal fibrosis.

Fields of Study & Subjects

Chronic Kidney Disease and Diabetes Extracellular vesicles in disease Cardiac Fibrosis and Remodeling

Publication details

Journal / source
Theranostics
Publisher
Ivyspring International Publisher
Volume
16
Issue
12
Pages
6988–7006
Publication date
18 May 2026
Language
EN