Systemic CSF1R Targeting Depletes Pathogenic MPS Bubs and Ameliorates Psoriasis via PPARα-mediated Resolution

Theranostics 2026 Open access

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Authors: Zhenjia Lin, Ying Li, Yangyinhui Yu, Mei-Jia Fang, Ying Xiong, Rui Xu, Zhuo Wang, Jun Feng Zhang, Yanan Xu, Jun-Ya Wan, Xiang Ji, Yufan Zheng
+8 more Kai-Lang Zhang, Ming Wei, Juntao Zou, Li-Xuan Jia, Hui Zhang, Chang-Lin Li, Li-Jun Zhou, Zhi Tan
DOI: 10.7150/thno.128248
Cited by: 1

Abstract

Our work delineates a unidirectional CSF1R-PPARα pathogenic axis and demonstrates that systemic CSF1R targeting is required to disrupt this circuit, providing a mechanistic foundation for a novel treatment strategy.

Fields of Study & Subjects

Psoriasis: Treatment and Pathogenesis Immune cells in cancer Spondyloarthritis Studies and Treatments

Publication details

Journal / source
Theranostics
Publisher
Ivyspring International Publisher
Volume
16
Issue
8
Pages
4336–4357
Publication date
30 January 2026
Language
EN