Lung dysbiosis disrupts an FFAR2-mediated innate immune circuit against Klebsiella pneumoniae

Theranostics 2026 Open access

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Authors: T.-K. Huang, Jheng-Syuan Shao, Alan Chuan‐Ying Lai, Ko-Chien Wu, Da-Fu Lin, Ya‐Jen Chang
DOI: 10.7150/thno.131136
Cited by: 3

Abstract

Rationale: lung infection, aiming to elucidate its functional significance in shaping pulmonary immune responses and susceptibility to bacterial pneumonia. Methods: or LPS via intranasal administration to establish lung infection. We further performed bulk RNA sequencing and reanalyzed single-cell RNA sequencing datasets to dissect microbiota-immune interactions in the lung. Cellular assays, cytokine profiling, gene expression analysis, acetate supplementation, and conditional knockout mice were used to further elucidate the underlying mechanisms. Result: , and FFAR2 is likewise enriched in human AMs, underscoring translational relevance. Conclusion: via SCFA-FFAR2 axis, a protective network disrupted by lung dysbiosis. These findings highlight the therapeutic potential of SCFA-FFAR2 targeting.

Fields of Study & Subjects

Gut microbiota and health Neutrophil Myeloperoxidase and Oxidative Mechanisms Pneumonia and Respiratory Infections

Publication details

Journal / source
Theranostics
Publisher
Ivyspring International Publisher
Volume
16
Issue
10
Pages
5348–5369
Publication date
12 March 2026
Language
EN