A dual functional theranostic microneedle patch for immunomodulation and real time monitoring in diabetic wound therapy

Theranostics 2026 Open access

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Authors: Shuai Fan, Junlong Zhong, Yeke Chen, Kang Chen, Zhiming Liu, Xinmin Yang, Wen Tan, Wenlong Tang, Wanhui Zhou, Degui Wu, Jiachao Xiong, Zhenhai Zhou
+2 more Fanrong Ai, Kai Cao
DOI: 10.7150/thno.133451
Cited by: 1

Abstract

Rationale: The management of diabetic wound is limited by the absence of delivery systems that can dynamically respond to the complex pathological microenvironment. Herein, we have engineered a dual-functional theranostic microneedle (MN) patch for intelligent diabetic wound therapy. Methods: levels. Results: -infected diabetic wound models, the patch significantly accelerated wound closure, promoting angiogenesis, collagen deposition, and re-epithelialization. Conclusion: This work pioneers a theranostic platform that integrates real-time diagnostic, controlled catalytic therapy, and immunomodulatory therapy, providing a viable approach to the autonomous management of chronic wounds.

Fields of Study & Subjects

Advancements in Transdermal Drug Delivery Wound Healing and Treatments Planarian Biology and Electrostimulation

Publication details

Journal / source
Theranostics
Publisher
Ivyspring International Publisher
Volume
16
Issue
12
Pages
6529–6553
Publication date
1 May 2026
Language
EN