Outpatient Treatment of Confirmed COVID-19 in Symptomatic Adults: Living, Rapid Practice Points From the American College of Physicians (Version 3)

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Authors: Amir Qaseem, Adam J. Obley, Jennifer Yost, George M. Abraham, Rebecca A. Andrews, Janet A. Jokela, Matthew C. Miller, Humphrey Ll, Ray Haeme, Alysa Krain, Thejaswi Poonacha, Sameer D. Saini
+20 more Timothy J Wilt, Kate Carroll, Itziar Etxeandia‐Ikobaltzeta, Curtis S. Harrod, Tatyana Shamliyan, Chelsea Vigna, Linda L. Humphrey, Adam J. Obley, Ray Haeme, Alysa Krain, Thejaswi Poonacha, Sameer D. Saini, Timothy J Wilt, Kate Carroll, Itziar Etxeandia‐Ikobaltzeta, Curtis S. Harrod, Amir Qaseem, Tatyana Shamliyan, Chelsea Vigna, Jennifer Yost
Cited by: 0
References: 5

Abstract

DESCRIPTION: The American College of Physicians (ACP) maintains living, rapid practice points on antiviral treatment in the outpatient setting for COVID-19. METHODS: The Population Health and Medical Science Committee (PHMSC) developed this version 3 based on evidence from a focused update of a living, rapid review conducted by the ACP Center for Evidence Reviews at Cochrane Austria. This version addresses the SARS-CoV-2 Omicron variant and reaffirms previous practice points on the use of antiviral treatments of confirmed COVID-19 in unvaccinated or vaccinated and symptomatic patients in the outpatient setting. RETIREMENT FROM LIVING STATUS: The PHMSC is retiring this topic from living status considering that this update and previous surveillance have not yielded important changes to the practice points.

Fields of Study & Subjects

COVID-19 Clinical Research Studies SARS-CoV-2 and COVID-19 Research Long-Term Effects of COVID-19

Publication details

Journal / source
Annals of Internal Medicine
Volume
179
Issue
4
Pages
559–563
Publication date
9 February 2026
Language
EN