COVID-19 Vaccines for 2025–2026 in Adults Who Are Not Pregnant or Immunocompromised: Rapid Practice Points From the American College of Physicians

Annals of Internal Medicine 2026

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Authors: Amir Qaseem, Adam J. Obley, Curtis S. Harrod, Timothy J Wilt, Kate L. Carroll, Linda L. Humphrey, Linda L. Humphrey, Adam J. Obley, Ray Haeme, Alysa Krain, Thejaswi K. Poonacha, Sameer D. Saini
+10 more Timothy J Wilt, Kate L. Carroll, Curtis S. Harrod, Amir Qaseem, Chelsea Vigna, Ray Haeme, Alysa Krain, Thejaswi Poonacha, Sameer D. Saini, Chelsea Vigna
DOI: 10.7326/annals-25-05026
Cited by: 1
References: 8

Abstract

DESCRIPTION: The American College of Physicians (ACP) developed these rapid practice points addressing the effectiveness, comparative effectiveness, and harms of Omicron-adapted COVID-19 vaccines in adults (aged ≥18 years) who are not pregnant or immunocompromised. METHODS: The ACP Population Health and Medical Science Committee developed the rapid practice points on the basis of a rapid review by the ACP Center for Evidence Reviews at Cochrane Austria and national disease surveillance data on the epidemiology and baseline risks for COVID-19. The following practice points apply to those who are not pregnant or immunocompromised.

Fields of Study & Subjects

COVID-19 Impact on Reproduction SARS-CoV-2 and COVID-19 Research Vaccine Coverage and Hesitancy

Publication details

Journal / source
Annals of Internal Medicine
Publisher
American College of Physicians
Volume
179
Issue
5
Pages
728–733
Publication date
23 February 2026
Language
EN