[Advances on efficacy and mechanisms of acid fibroblast growth factor for promoting injured tissue repair].

Objective: To review the research progress on acid fibroblast growth factor (aFGF) in promoting tissue injury repair and its mechanism of action. Methods: By searching and reviewing the basic and clinical studies on aFGF published in recent years, the roles of aFGF in tissue injury including full-thickness skin, skin and mucous barrier, bone and nerve fiber were summarized. Results: As a key member of the FGF family, aFGF exhibits potent mitogenic activity, it can regulate various cells proliferation and migration, accelerate extracellular matrix synthesis, promote angiogenesis and nerve fiber repair, upregulate tight junction protein expression, and therefore exert dual regulatory effects on dermal and epidermal regeneration and repair. It demonstrates promising clinical application for full-thickness healing and skin and mucous barriers repair. Additionally, it mediates the regeneration and differentiation of osteoblasts, cardiomyocytes, and follicle cells, exhibiting potential for repairing multiple tissues and organs. Furthermore, the aFGF's functions in regulating energy metabolism, immune-inflammatory responses, and alleviating aging have revealed in recent years, indicating a broad clinical application. Conclusion: aFGF is a valuable member of the FGF family. It is widely used in various kinds of wound healing, besides, it also holds promising application in multiple tissue and organ regeneration and repair.