Reviewer #2 (Public review): Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain

Using a combination of innovative and robust techniques, this study outlines cell-type-specific translational landscape changes that occur in the spinal cord neurons in the early and late phases of nerve injury.The authors provided compelling evidence suggesting an essential role of protein synthesis regulation in the chronic phase of neuropathic pain.Although additional mechanisms contributing to late-phase neuropathic pain beyond altered PV+ neuron excitability remain to be elucidated, this is a fundamental and significant study toward a comprehensive understanding of the molecular pathways involved in neuropathic pain.