eLife Assessment: Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi–Goutières syndrome neuropathology
Abstract
A microglia replacement approach demonstrates that brain macrophages with patient mutations from Aicardi–Goutières syndrome, a genetic, brain predominant interferonopathy, are sufficient to drive interferon responses.
Fields of Study & Subjects
Neuroinflammation and Neurodegeneration Mechanisms
interferon and immune responses
Inflammasome and immune disorders
Publication details
- Publication date
- 27 January 2026