Author response: Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi–Goutières syndrome neuropathology

Kelsey Marie Nemec; Genevieve Gucci Grace Capispisan Uy; V Sai Chaluvadi; Freddy S Purnell; Bilal Elfayoumi; Leila Byerly; Micaela L. O’Reilly; Carleigh A. O’Brien; William H. Aisenberg; Sonia I Lombroso; Xinfeng Guo; Niklas Blank; Chet Huan Oon; Fazeela Yaqoob; Brian Temsamrit; Priyanka Rawat; Christoph A. Thaiss; Will Bailis; Adam P. Williamson; Qingde Wang; Mariko L. Bennett; F. Chris Bennett

doi:10.7554/elife.102900.3.sa3

Author response: Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi–Goutières syndrome neuropathology

2026 Open access

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Authors: Kelsey Marie Nemec, Genevieve Gucci Grace Capispisan Uy, V Sai Chaluvadi, Freddy S Purnell, Bilal Elfayoumi, Leila Byerly, Micaela L. O’Reilly, Carleigh A. O’Brien, William H. Aisenberg, Sonia I Lombroso, Xinfeng Guo, Niklas Blank

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Chet Huan Oon, Fazeela Yaqoob, Brian Temsamrit, Priyanka Rawat, Christoph A. Thaiss, Will Bailis, Adam P. Williamson, Qingde Wang, Mariko L. Bennett, F. Chris Bennett

DOI: 10.7554/elife.102900.3.sa3

Cited by: 0

Abstract

A microglia replacement approach demonstrates that brain macrophages with patient mutations from Aicardi–Goutières syndrome, a genetic, brain predominant interferonopathy, are sufficient to drive interferon responses.

Fields of Study & Subjects

Neuroinflammation and Neurodegeneration Mechanisms interferon and immune responses Inflammasome and immune disorders

Publication details

Publication date: 27 January 2026