eLife Assessment: Progressive overfilling of readily releasable pool underlies short-term facilitation at recurrent excitatory synapses in layer 2/3 of the rat prefrontal cortex
Abstract
Excitatory recurrent synapses in the upper pyramidal layer of the prefrontal cortex exhibit delayed short-term facilitation, despite very high vesicular fusion probability, through synaptotagmin 7-dependent overfilling of release sites.
Fields of Study & Subjects
Neuroscience and Neuropharmacology Research
Cellular transport and secretion
Neural dynamics and brain function
Publication details
- Journal / source
- eLife
- Publication date
- 10 February 2026
- Language
- EN