eLife Assessment: Single-nucleus transcriptional and chromatin accessibility analyses of maturing mouse Achilles tendon uncover the molecular landscape of tendon stem/progenitor cells

This study presents a valuable finding of novel markers that may potentially identify resident tendon stem/progenitor cells (TSPCs).The study also presents a comprehensive single-cell transcriptional dataset that will be of value to the field.The evidence supporting the identification of novel markers of a TSPC is incomplete, requiring clarification of current analyses and additional validation experiments to demonstrate that these markers are indeed specific and these cells are indeed TSPCs.This work will be of interest to biologists and engineers focused on tendons and ligaments.