eLife Assessment: Cross-species evaluation of TANGO2 homologs, including HRG-9 and HRG-10 in Caenorhabditis elegans, challenges a proposed role in heme trafficking

eLife AssessmentThis valuable study provides solid evidence that supports TANGO2 homologs, including HRG-9 and HRG-10, can play a role in cellular bioenergetics and oxidative stress homeostasis.It also challenges the previously reported role of TANGO2 in heme transport and paves the way for future mechanistic studies addressing the mechanisms of how TANGO2 regulates oxidative stress homeostasis.The strengths include the use of different model systems, genetic tools, behavioral assays, and efforts by the authors in using the same reagents to reproduce results of other groups.