eLife Assessment: Affinity-guided labeling reveals P2X7 nanoscale membrane redistribution during BV2 microglial activation
Abstract
An affinity-guided chemical strategy enabling highly specific biotinylation of P2X7 receptors reveals, by super-resolution microscopy, how the nanoscale organization of endogenous P2X7 in BV2 microglial cells dynamically changes upon activation.
Fields of Study & Subjects
Adenosine and Purinergic Signaling
Neuroinflammation and Neurodegeneration Mechanisms
Advanced Fluorescence Microscopy Techniques
Publication details
- Publication date
- 9 January 2026