Author response: Aggregation-dependent epitope sequence and modification fingerprints of anti-Aβ antibodies

eLife 2026 Open access

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Authors: Ivan Talucci, Timon Leske, Hans‐Wolfgang Klafki, Mohammed Mehedi Hassan, Annik Steiert, Bárbara Morgado, Sebastian Bothe, Lars v. Werven, Thomas Liepold, Jochen Walter, Hermann Schindelin, Jens Wiltfang
+3 more Oliver Wirths, Olaf Jahn, Hans Michael Maric
DOI: 10.7554/elife.106156.3.sa2
Cited by: 0

Abstract

Comprehensive residue-level mapping of amyloid-beta recognition reveals how sequence variants, post-translational modifications, and aggregation state shape antibody specificity, thereby guiding selection and development of therapeutic antibodies in Alzheimer’s disease.

Fields of Study & Subjects

Alzheimer's disease research and treatments Monoclonal and Polyclonal Antibodies Research Dementia and Cognitive Impairment Research

Publication details

Journal / source
eLife
Publication date
9 February 2026
Language
EN