eLife Assessment: BICC1 interacts with PKD1 and PKD2 to drive cystogenesis in ADPKD
Abstract
The RNA-binding protein BICC1 can act as a genetic disease modifier for kidney cyst formation, potentially explaining the high variability of disease onset and severity in autosomal-dominant polycystic kidney disease patients.
Fields of Study & Subjects
Genetic and Kidney Cyst Diseases
Tuberous Sclerosis Complex Research
Cystic Fibrosis Research Advances
Publication details
- Journal / source
- eLife
- Publication date
- 12 February 2026
- Language
- EN