Author response: BICC1 interacts with PKD1 and PKD2 to drive cystogenesis in ADPKD

eLife 2026 Open access

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Authors: Uyen Tran, Andrew J. Streets, Devon Smith, Decker Eva, Annemarie Kirschfink, Lahoucine Izem, Jessie M Hassey, Briana Rutland, Manoj Kumar Valluru, Jan Hinrich Bräsen, Elisabeth B. Ott, Daniel Epting
+4 more Tobias Eisenberger, Albert C.M. Ong, Carsten Bergmann, Oliver Wessely
DOI: 10.7554/elife.106342.3.sa4
Cited by: 0

Abstract

The RNA-binding protein BICC1 can act as a genetic disease modifier for kidney cyst formation, potentially explaining the high variability of disease onset and severity in autosomal-dominant polycystic kidney disease patients.

Fields of Study & Subjects

Genetic and Kidney Cyst Diseases Tuberous Sclerosis Complex Research Cystic Fibrosis Research Advances

Publication details

Journal / source
eLife
Publication date
12 February 2026
Language
EN