eLife Assessment: GMCL1 controls 53BP1 stability and modulates taxane sensitivity

eLife AssessmentThis study identifies 53BP1 as an interaction partner of GMCL1 (a likely CUL3 substrate receptor).The study proposes a novel mechanism by which cancer cells evade the mitotic surveillance pathway through GMCL1-mediated degradation of 53BP1, leading to reduced p53 activation and paclitaxel resistance.These data are the most useful aspect of the study, but the data supporting the authors' conclusions as to the clinical relevance of the study are inadequate.The authors have not taken relevant data about the clinical mechanism of taxanes into account.