eLife Assessment: A high-resolution analysis of arrestin2 interactions responsible for CCR5 endocytosis

The authors investigate arrestin2-mediated CCR5 endocytosis in the context of clathrin and AP2 contributions.Using an extensive set of NMR experiments, and supported by microscopy and other biophysical assays, the authors provide compelling data on the roles of AP2 and clathrin in CCR5 endocytosis.This important work will appeal to an audience beyond those studying chemokine receptors, including those studying GPCR regulation and trafficking.The distinct role of AP2 and not clathrin will be of particular interest to those studying GPCR internalization mechanisms.