Author response: Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment

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Authors: Nicholas G. Tolman, Taibo Li, Revathi Balasubramanian, Guorong Li, Rebecca L. Pfeiffer, Violet Bupp-Chickering, Ruth A. Kelly, Marina Simón, John Peregrin, Christa Montgomery, Bryan William Jones, Dan Stamer
+2 more Jiang Qian, Simon W. M. John
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Abstract

Single-cell transcriptomics identifies three discrete mouse trabecular meshwork subtypes and demonstrates that an Lmx1b glaucoma mutation drives mitochondrial dysfunction and elevated intraocular pressure, which is lessened by vitamin B3 supplementation.

Fields of Study & Subjects

Glaucoma and retinal disorders Single-cell and spatial transcriptomics Connexins and lens biology

Publication details

Publication date
20 January 2026