Reviewer #4 (Public review): In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies

Yanqing Yang; Lulu Qiao; Yangwei Jiang; Zhiye Wang; Dong Zhang; Damiano Buratto; Liquan Huang; Ruhong Zhou

doi:10.7554/elife.107785.3.sa1

Reviewer #4 (Public review): In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies

2026 Open access

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Authors: Yanqing Yang, Lulu Qiao, Yangwei Jiang, Zhiye Wang, Dong Zhang, Damiano Buratto, Liquan Huang, Ruhong Zhou

DOI: 10.7554/elife.107785.3.sa1

Cited by: 0

Abstract

Computer-Aided Aptamer Modeling and Optimization (CAAMO) enables structure-guided RNA aptamer affinity maturation, producing a SARS-CoV-2 RBD (receptor binding domain) binder that rivals neutralizing antibodies and retains predicted activity across variants.

Fields of Study & Subjects

Advanced biosensing and bioanalysis techniques RNA Interference and Gene Delivery RNA and protein synthesis mechanisms

Publication details

Publication date: 17 June 2026