Author response: Allosteric effects of the coupling cation in melibiose transporter MelB

2026 Open access

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Authors: Parameswaran Hariharan, Yuqi Shi, Amirhossein Bakhtiiari, Ruibin Liang, Rosa I. Viner, Lan Guan
DOI: 10.7554/elife.108335.3.sa3
Cited by: 0

Abstract

Intrinsic conformational flexibility of a solute transporter is restrained by substrates, resulting in Na+ allosterically enhancing primary substrate binding through cooperative constraints on the dynamics of the cytoplasmic inner barrier.

Fields of Study & Subjects

Drug Transport and Resistance Mechanisms Protein Structure and Dynamics Ion Transport and Channel Regulation

Publication details

Publication date
28 January 2026