Reviewer #2 (Public review): A genome-wide MAGIC kit for recombinase-independent mosaic analysis in Drosophila
Abstract
eLife AssessmentThe study showcases a significant and important enhancement of the MAGIC transgenesis method, by extending it genome-wide to all chromosomes.The authors provide compelling evidence to demonstrate that the MAGIC mosaic clones can be generated for genes from all, including the 4th chromosome.With this toolkit extension, the method is set to complement the classical FRT/Flp recombination system for gene manipulation in flies.
Fields of Study & Subjects
CRISPR and Genetic Engineering
Developmental Biology and Gene Regulation
Neurobiology and Insect Physiology Research
Publication details
- Journal / source
- eLife
- Publication date
- 3 March 2026
- Language
- EN