eLife Assessment: Suppression of interferon signaling via small-molecule modulation of TFAM
Abstract
Small-molecule mitochondrial transcription factor A modulators stabilize mtDNA, preventing cytosolic escape and suppressing cGAS-STING interferon signaling, while improving bioenergetics and fibrosis markers in disease models.
Fields of Study & Subjects
interferon and immune responses
Mitochondrial Function and Pathology
Autophagy in Disease and Therapy
Publication details
- Publication date
- 6 February 2026