Author response: Overexpression of Ssd1 and calorie restriction extend yeast replicative lifespan by preventing deleterious age-dependent iron uptake

2026 Open access

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Authors: Ignacio gutierrez, Claudia L. Edgar, Jessica K. Tyler
DOI: 10.7554/elife.108892.3.sa4
Cited by: 0

Abstract

Live imaging analyses in budding yeast reveal that calorie restriction and overexpression of the mRNA binding protein Ssd1 both block deleterious age-dependent iron uptake as a mechanism to extend lifespan.

Fields of Study & Subjects

Genetics Aging and Longevity in Model Organisms Autophagy in Disease and Therapy Fungal and yeast genetics research

Publication details

Publication date
12 January 2026