Author response: The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements

This work offers important insights into the protein CHD4's function in chromatin remodeling and gene regulation in embryonic stem cells, supported by extensive biochemical, genomic, and imaging data.The use of an inducible degron system allows precise functional analysis, and the datasets generated represent a key resource for the field.The revised study offers compelling evidence and makes a significant contribution to understanding CHD4's role in epigenetic regulation.This work will be of interest to the epigenetics and stem biology fields.