Reviewer #2 (Public review): Accessibility of the unstructured α-tubulin C-terminal tail is controlled by microtubule lattice conformation
Abstract
Three newly developed biosensors demonstrate that the C-terminal tail of α-tubulin does not freely extend from the microtubule surface as widely thought, but rather is inaccessible along most microtubules in cells.
Fields of Study & Subjects
Microtubule and mitosis dynamics
Advanced Fluorescence Microscopy Techniques
Genetic and Kidney Cyst Diseases
Publication details
- Journal / source
- eLife
- Publication date
- 9 February 2026
- Language
- EN