Author response: Accessibility of the unstructured α-tubulin C-terminal tail is controlled by microtubule lattice conformation

eLife 2026 Open access

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Authors: Takashi Hotta, Morgan L. Pimm, Ezekiel C. Thomas, Yang Yue, Patrick Ryan DeLear, Lynne Blasius, Michael A. Cianfrocco, Morgan E. DeSantis, Ryota Horiuchi, Takumi Higaki, David Sept, Ryoma Ohi
+1 more Kristen J. Verhey
DOI: 10.7554/elife.109308.3.sa4
Cited by: 0

Abstract

Three newly developed biosensors demonstrate that the C-terminal tail of α-tubulin does not freely extend from the microtubule surface as widely thought, but rather is inaccessible along most microtubules in cells.

Fields of Study & Subjects

Microtubule and mitosis dynamics Advanced Fluorescence Microscopy Techniques Genetic and Kidney Cyst Diseases

Publication details

Journal / source
eLife
Publication date
9 February 2026
Language
EN