eLife Assessment: Butyrate rescues chlorpyrifos-induced social deficits through inhibition of class I histone deacetylases

This valuable manuscript demonstrates that embryonic exposure to the pesticide chlorpyrifos (CPF) impairs juvenile zebrafish social behavior and sets out to define the underlying mechanism.The authors provide solid evidence that butyrate and class I histone deacetylases are involved, as their modulation rescues the phenotype.However, claims that CPF acts through the microbiome and nitric oxide signaling remain correlative and incomplete.Additional validation would strengthen the intriguing hypotheses raised by this work.