Reviewer #1 (Public review): Molecular architecture of the tumor microenvironment caused by BRCA1 and BRCA2 somatic mutations in lung adenocarcinoma

eLife AssessmentThis important study investigates the impact of BRCA1/2 mutations on immunotherapy in lung adenocarcinoma using multi-omics approaches.The detailed genetic analysis of two cancer genes (BRCA1 and BRCA2) demonstrated new roles for these genes in causing the tumor microenvironment in lung cancer.Further experimental explorations of the immune-related changes may still be required.The solid findings of this study provide a foundation for further developing drugs targeting BRCA1/2 in lung cancer therapy.