eLife assessment: Polymorphisms in intron 1 of HLA-DRA differentially associate with type 1 diabetes and celiac disease and implicate involvement of complement system genes C4A and C4B
Abstract
HLA-DRA intronic haplotype associates with opposite effects on type 1 diabetes and celiac disease, refining genetic risk prediction and implicating complement genes C4A and C4B in divergent autoimmune pathways.
Fields of Study & Subjects
Diabetes and associated disorders
Genetic Associations and Epidemiology
Celiac Disease Research and Management
Publication details
- Publication date
- 2 February 2026